Pharmaceutical methods of identifying fibrinolytic activity

Abstract

Abstract: Thrombosis disease is the most serious human diseases in the world, but there is not efficient therapeutic drug.And the animal, plant and microorganism from nature supply vast resources in the development of anti-thrombosis drug research.Some nature products, such as Urokinase, Nattokinase, Hirudin, Lumbrokinase, have been developed as the drug of anti-thrombosis, and play a certain role during treatment. Fibrinolytic enzyme and plasminogen kinase can direct dissolution the fibrin, then cause thrombosis disappearance.The research and developing of the novel type fibrinolytic enzyme is the best way to treat the thrombosis disease, and the establishing easy, rapid method on anti-thrombosis activity is the key point in this research.This article reviews the method of identifying the anti-clotting activity and provides some datas to improve the assay of thrombolysis.

Key words: antithrombosis, fibrinolyticenzyme, plasminogenkinase, activityassay

CLC Number:

R973⁺.2

LI Hua, CHEN Ling-xia, XU Rui-an. Pharmaceutical methods of identifying fibrinolytic activity[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(9): 1066-1070.

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