Abstract: AIM: To observe the changes of endodermis of stable angina patients and the effect of Salvianolate injection intervention. METHODS: 82 stable angina patients were chosen and randomly divided into two groups:one group was given conventional therapy, the other was added to Salvianolate injection in the base of conventional therapy.The treatment course was two weeks.The levels of NO, ET and VEGF were observed before and after treament. RESULTS: The anginal symptom of both two group patients were relieved.ET value was significantly decreased and the NO, VEGF value significantly increased in Salvianolate injection group more than before treament. CONCLUSION: Stable angina patients exist endodermis function damage.Salvianolate injection can effectually improve the endothelial function and relieve the anginal attack.

Key words: stable angina, endothelial function, Salvianolate