Advances on the causes and strategies of clopidogrel resistance

Abstract

Abstract: As we all know, platelets play a key role in the formation of arterial thrombosis and antiplatelet therapy has become the cornerstone for the prevention and treatment of arterial thrombosis in patients with acute coronary syndrome.Clopidogrel is a new antiplatelet drug, which has been confirmed as an important adjuvant therapy of cardiovascular disease.However, Many studies have found that about 11 %-44 %of patients show low response even non-response to clopidogrel, which is defined as clopidogrel resistance.The causes, which lead to this resistance phenomenon, may be due to inadequate doses of clopidogrel administration, the individual gene polymorphism, drug interactions and so on.The main strategies of clopidogrel resistance include increasing doses of clopidogrel administration, combining with other antiplatelet drugs, reducing adverse drug interactions and using of new drugs.

Key words: clopidogrel resistance, platelet aggregation

CLC Number:

YU Chang-yong, ZHANG Yong, ZOU Jian-jun, YAN Xiang, MA Hai-tao, NI Bin, ZHU Yu-bing, FAN Hong-we, HE Chun-hui. Advances on the causes and strategies of clopidogrel resistance[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(10): 1168-1173.

References

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