Effect ofWuling capsule in the treatment of patients with gastroesophageal reflux disease accompanied with anxiety

Abstract

Abstract: AIM: To explore the efficacy of Wuling capsule in the treatment of gastroesophageal reflux disease (GERD) accompanied with anxiety. METHODS: 64 patients with gastroesophageal reflux disease accompanied with anxiety(the score of the SAS ≥50) were randomly divided into 2 groups.Study group(n = 32) was treated with Wuling capsule and esomeprazole magnesium tablets for 8 weeks and control group was treated with esomeprazole magnesium tablets.Clinical efficacy was assessed with gastroesophageal reflux symptoms and Zung self-rating anxiety scale (SAS). RESULTS: After 8 weeks treatment, the efficacy rate and total effective rate of study group were 58.6 %and 93.1 %, which were significantly higher than those in the control group(32.2 % and 67.9 %, respectively, P <0.05).Scores of the SAS of both groups were significantly reduced(P <0.01);and scores of the SAS were significantly different between the study group and the control group after 4, 8 weeks treatment(P <0.05, P <0.01). CONCLUSION: Wuling capsule has significant effectiveness and high safety in the treatment of GERD accompanied with anxiety.

Key words: Wuling capsule, esomeprazole magnesium tablets, gastroesophageal reflux disease, anxiety

CLC Number:

R571

CHEN Xiao-yan, YAN Jun, CAI Zhen-zhai, XIA Xuan-ping, ZHENG Jun-jie, XUE Zhan-xiong. Effect ofWuling capsule in the treatment of patients with gastroesophageal reflux disease accompanied with anxiety[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(11): 1300-1303.

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