Abstract: AIM: To detect the concentrations of solube tumor necrosis factor receptors (sTNF-R1 and sTNF-R2) at prostatic secretion in male patients with chronic pelvic pain syndrome(CPPS).And to investi-gate the potential roles of sTNF-R1 and sTNF-R2 in the development of CPPS inflammation. METHODS: All the patients were obtained during March 2008 to January 2009 including 24 cases of CPPS ⅢA and 20 cases of CPPS ⅢB, and were compared to 24 cases of volunteers. Expressed prostatic secretion were obtained by rectum massage methods.Concentrations of sTNF-R1 and sTNF-R2 were measured by enzyme linked immunosorbent assay methods. RESULTS: The concentrations of sTNF-R1 and sTNF-R2 proteins were significantly higher from CPPS ⅢA group than those from CPPS ⅢB group [ (46 ±6 vs 41 ±6), P <0.05, (13.0 ±4.8 vs 7.9 ±4.1) ng/mL, P <0.01], and they were dramaticly higher from CPPS ⅢB group than those from compared group [(25 ±8), (2.5 ±1.9) ng/mL, all P <0.01]. CONCLUSION: Concentrations of sTNF-R1 and sTNF-R2 proteins are increased in male patients with CPPS.Both of them may be associated with the development of CPPS inflammation.

Key words: chronic pelvic pain syndrome, tumor necrosis factor, receptor, enzyme linked immunosorbent assay