Membrane proteins and membrane proteomics

Abstract

Abstract: A membrane protein is a protein molecule that is attached to, or integrated into the membrane of a cell or an organelle.As the membrane protein is a good target for drugs, more than 80 % of the drugs on the present market take the effect on the membrane protein.Therefore, it is significant to study the membrane proteins.However, the traditional study on membrane proteomics is obstructed by the difficulties in solubilizing, separating, and identifying membrane proteins.This review summarizes the structure of membrane proteins, the significant role of the membrane proteins on the cell physiology and the human diseases, the potential of the membrane proteins to be the target for drugs and the techniques of the research on the membrane proteomics.

Key words: membrane proteins, membrane proteomics, drug target

CLC Number:

R966

LIANG Yan, KAN Hong-wei, YANG Shi-you. Membrane proteins and membrane proteomics[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(11): 1313-1320.

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