Abstract: AIM: To observe the effects on the expressions of P-selectin and MPO induced by cerebral ischemia reperfusion injury in the rats after using atorvastatin.METHODS: SD rats were randomly divideded into sham operation group( Sham), cerebral ischemia reperfusion group( CIR) and atorvastatin group( ATO). Aatorvastatin was given via intragastrical.ATO group were divided into four weeks, two weeks, three days later and the immediate subgroup.Sham and CIR groups were divided into 6, 12, 24, 48, 72 hours subgroups, and were examined 12, 24 hours later.The expressions of P-selectin by immunohistochemistry technique and the contents of MPO in brain tissue homogenate were detected.RESULTS: The expressions of Pselectin were increased obviously at 6 h after ischemia reperfusion, the peak was at 12 h, then gradually were decreased, small amounts were expressed at 3 d.The expressions of P-selectin were down-regulation, after using atorvastatin, and there were remarkable differences in ATO group ( P <0.01).Compared with Sham group, the contents of MPO were increased remarkably in CIR group ( P <0.01).There was a linear positive correlation between the expressions of P-selectin and the contents of MPO.The contents of MPO in brain homogenate were decreased treated with atorvastatin and acenterine.There was statistical significance within ATO group( P <0.05).CONCLUSION: The expressions of P-selectin and the contents of MPO are increased after cerebral ischemia reperfusion, and decreased after using atorvastatin ( r =0.883, P < 0.05).

Key words: cerebral ischemia reperfusion, P-selectin, myeloperoxidase, atorvastatin