Diabetes and ATP-binding cassette transporters

Abstract

Abstract: Diabetes is a common systematic disease.It was reported that complications of diabetes such as hyperlipemia, atherosclerosis and cardiomyopathies might result from disorders of blood glucose, blood lipid and hormone homeostasis.It was reported that four subfamilies of the ATP-binding cassette (ABC) transporter such as ABCA, ABCB, ABCC and ABCG, play important roles in this modulation.ABCA1 and ABCG1 export excess cellular cholesterol into the HDL pathway, reduce cholesterol accumulation in macrophages and prevent from translation of macrophages into “foam cells” in the artery wall.ABCG5 and ABCG8 limit absorption of dietary sterols in the intestine and promote cholesterol elimination from the body through hepatobiliary secretion.ABCC8, as a untypical transporter, regulates ATP-sensitive K + channels in insulin- secreting pancreatic β cells to maintain the glucose homeostasis.ABCB1, ABCC1-ABCC5 and ABCG2 are common efflux transporters of drugs, that influence their substrates'physiological disposition.Mutations of these subfamilies of ABC transporters may induce diabetes and its complications.The function and expression of ABC transporters may be impaired under diabetes condition, in turn which intensify the diabetes and its complications.Here, the relationship between the diabetes and four subfamilies of ABC transporters is reviewed in order to provide some new ideas and new targets for the study of diabetes.

Key words: ATP-Binding cassette transporters, diabetes, dyslipidemia, KATP, channels

CLC Number:

R587.1

LIU Xiang, LIU Xiao-dong. Diabetes and ATP-binding cassette transporters[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(12): 1428-1435.

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