Abstract: AIM: To observe the changes of hepatic fibrosis index, clinical symptom, physical sign and hepatic function after the patients were treated treatment with reduced glutathione hormone.METHODS: The 72 patients were divided into two groups that one was the treatment group with 37 patients and the other was the control group with 35 patients.The control group was accepted the treatment with Ganlixin Injection, Magnesium Aminosuccinate Injection and Mulvital, etc.The treatment group was accepted reduced glutathione hormone(1.5 g, once a day) in addition. The course of treatment lasted for 8 weeks.We observed the two groups'blood-serum fibrosis indexes (HA, LN, PIII-P, C-IV) and biochemistry indxes (TBIL, ALT, AST, GGT) before and after the treatment.RESULTS: The improvements of the treatment group were much better than the control group on the sides of clinical symptom, physical sign, hepatic function and blood-serum fibrosis.The treatment group's blood-serum fibrosis indexes were much lower after the treatment(P <0.01), and there was no clear decline in the control group.There were obvious differences between the two groups(P <0.01).CONCLUSION: Reduced glutathione hormone has the significant effects of anti-fibrosis and liver protection.

Key words: reduced glutathione hormone, alcoholic hepatitis, hepatic fibrosis