Welcome to Chinese Journal of Clinical Pharmacology and Therapeutics,Today is Chinese

Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2009, Vol. 14 ›› Issue (2): 195-198.

Previous Articles     Next Articles

Clinical features and prognosis of obstructive and non-obstructive hypertrophic cardiomyopathy patients

TANG Yuan-yuan1,2, TANG Bo-jian2, YAN Xiao-wei2, FANG Quan2   

  1. 1People's Hosital of Xuancheng's Squail, Wuhu 241001, Anhui, China;
    2Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
  • Received:2009-01-08 Revised:2009-02-06 Online:2009-02-26 Published:2020-10-30

Abstract: AIM: To compare and analyse the clinical features and outcomes between obstructive and non-obstructive hypertrophic cardiomyopathy (HCM). METHODS: We made a retrospective analysis of the clinical data of 112 patients(54 patients were obstructive HCM and 58 patients were non-obstructive HCM)) admitted in our hospital from 2003 to 2006 with the diagnosis of HCM, and followed up for (4.5 ±2.8) years.RESULTS: There were no significant differences in age, family history and complications between obstructive and non-obstructive HCM patients.The proportion of female patients was markedly higher in the obstructive HCM patients than that in the non-obstructive HCM patients.Besides chest distress and heart murmur were more obvious in the obstructive HCM patients, there was no significant difference between the two groups as to other clinical symptoms, signs and clinical outcome.The differences in systolic anterior motion of the mitral valve(SAM sign), maximum pressure gradient in the left ventricular outflow tract (LVOT), left ventricular ejection fraction(LVEF), left atrial diameter, mitral valve regurgitation reached sinificance between the obstructive HCM group and the non-obstructive HCM group.The incidence of clinical events was low in follow-up period, and there was no difference between the two groups.CONCLUSION: There were no significant differences in age, family history and, complications between obstructive and non-obstructive HCM patients.After β blocker-based drug treatment, the incidence of clinical and cardiac events were relatively low.

Key words: obstructive hypertrophic cardiomyopathy, non-obstructive hypertrophic cardiomyopathy, clinical outcome

CLC Number: