Abstract: AIM: To evaluate the effectiveness and safety of combination lornoxicam and Dexamethasone on preemptive analgesia in perioperative of lower limbs. METHODS: 100 patients undergoing lower limbs operation were randomly divided into four groups:group A (n =25) received lornoxicam 8 mg and Dexamethasone 10 mg, group B (n =25) received lornoxicam 8 mg and normal saline, group C (n =25) received dexamethasone 10 mg and normal saline, group D (n = 25) received only normal saline.The corresponding medicines were given at 30 min before anesthesia by intravenous injection, the epidural anesthesia were used during operation, and the. four groups received postoprerative patient-controlled intravenous analgesia (PCIA).The visual analogue scores (VAS) after operation 2, 4, 8, 12, 24 h were recorded and the pointed pain degree (PD), the medium pain degree (MD) after operation 48 h and the Bruggrmann comfort scale (BCS), the somnus scale (SS) were utilized to evaluate analgesia effect and the degree of patients analgesia satisfaction.After operation, the utilization imformations of aid drugs were recorded and the correlated side-effects were observed, such as nausea, disgorging, Itch of skin, drowsiness, infection of incisional wound, delay unrecovery. RESULTS: There were significant differences on group D in the VAS pain scores and Bruggrmann comfort scale at 2, 4, 8, 12, 24, 48 after the operation compared with group A and B (P<0.05). The VAS pain scores in group A decreased at 2, 4, 8, 12 h after the operation (P<0.05) compared with group B, and the PD, MD, SS scores in group A decreased after the operation (P<0.05) compared with the other groups.The consumed aid drugs in group A, B were less than that in group C, D(P<0.05).The incidence rates of nausea, disgorging in group A were lower than that in group B and C and D (P<0.05). CONCLUSIONS: The combination of lornoxicam and Dexamethasone gets more satisfactory analgesia effects and less correlated adverse effects in perioperation of lower limbs.

Key words: lornoxicam, non-steroidal anti-inflammatory drug, preemptive analgesia, Dexamethasone, patient-controlled intravenous analgesia