Effects of salvianolic acid capsule on acute myocardial ischemia in Beagle dogs

Abstract

Abstract: AIM: To observe the effect of salvianolic acid capsule on acute myocardial ischemia in Beagle dogs.METHODS: 56 Beagle dogs weighting (12±2) kg were randomly divided into 7 groups, which including sham operation group, model control group, salvianolic acid capsule group(25, 50, 100 mg/kg) , salvia tablets group(275 mg/kg) , Diaoxinxuekang capsule group (100 mg/kg ).The acute myocardial ischemia model in Beagle dogs were established by ligating anterior descending coronary artery after duodenal administration.The degree of myocardial ischemia was detected by epicardial electro gram mapping and the area of myocardial infarction was determined by NBT immunohistochemistry.The levels of serum CK and LDH were detected.The heart muscle ischemia protection of salvianolic acid capsule were observed.RESULTS: The salvianolic acid capsule could degrade the extent of heart muscle ischemia (Σ-ST) , decrease the range of heart muscle ischemia(N-ST) , deflate the myocardial infarction size (MIS) , relieve the levels of serum CK and LDH significantly, and relieve the injury degree of cadiocyte.CONCLUSION: Salvianolic acid capsule has remarkable protective effect on acute myocardial ischemia in Beagle dogs.

Key words: salvianolic acid capsule, Beagle dog, myocardial ischemia

CLC Number:

R542.2

ZHANG Shan-fei, CHEN Min-li, CHAI Jian-guo, PAN Yong-ming, YING Hua-zhong, CHEN Liang, XU Jian-qin, ZHU Ke-yan, YE Hong. Effects of salvianolic acid capsule on acute myocardial ischemia in Beagle dogs[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(4): 416-420.

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