Abstract: AIM: To investigate the dynamic change of thromboxane prostacyclin in renal ischemia reperfusion injury rabbits, and approach the regulatory effects of ligustrazine injection on renal ischemia reperfusion injury and its mechanisms. METHODS: Thirty rabbits were divided into three groups randomly:sham operation group (group S), ischemia reperfusion injury group (group IR) and ischemia reperfusion injury plus ligustrazine injection group (group LZ), each group had ten rabbits.The renal ischemia reperfusion injury model of rabbit was established in vivo.The content of thromboxane B₂ (TXB₂), 6-keto-prostaglandin F_1α(6-keto-PGF_1α) were detected in the blood plasma gathered from common carotid artery at times:pre-ischemia, ischemia 1 h, reperfusion 1, 3 and 5 h, the ratio of TXB₂ and 6-keto-PGF_1αwere calculated.The content and the ratio of TXB₂ and 6-keto-PGF_1α in kidney tissue were detected at the end of the experiment. RESULTS: The content of TXB₂ in plasma showed a time-dependent ascensus in group IR during ischemia reperfusion, it was significant higher than that in group S at all time points (all P<0.01).Compared withgroup IR and with group S, the content of TXB₂ in plasma was decreased significantly in group LZ at each time point during ischemia reperfusion (all P<0.01). Compared with group S, there was not different significance for the TXB₂ 6-keto-PGF_1α in group LZ(all P> 0.05).Compared with group IR, it was significant lower in group LZ at each of time point (all P<0.01). Compared with group IR, in group LZ, the TXB₂ level and TXB₂ 6-keto-PGF_1α in kidney tissue were decreased remarkably (all P<0.01), there was no different significances in 6-keto-PGF_1α (P>0.05). CONCLUSION: Ligustrazine could inhibit platelet to release TXA₂, regulate the balance of TXA₂/PGI₂, restrain no reflow phenomenon, so it could prevent renal ischemia reperfusion injury.

Key words: ligustrazine, kidney, ischemia reperfusion injury, thromboxane A₂, prostacyclin