Abstract: AIM: To study the effects of Wuzhicapsule (WZ) on the blood concentrations of Tacrolimus (Tac) in renal transplant recipients.METHODS: The renal transplant recipients were divided into experimental group (45 cases) which treated with Tac plus WZ and control group (45 cases) which were received Tac alone.The blood concentrations of Tac and biochemical values of hepatic and renal functions were determined.RESULTS: The blood concentrations of Tac were significantly higher in experimental group than those in experimental group before combined with WZ(P<0.01) or in control group (P<0.01).The biochemical values of hepatic and renal functions between experimental group and control group were no significant difference.CONCLUSION: The WZ can markedly elevate the blood concentrations of Tac in renal transplant recipients and does not increase the liver and kidney toxicity of Tac at the same time.The treatment of WZ combined with Tac can reduce the dosages and costs of Tac in renal transplant recipients.

Key words: renal transplantation, tacrolimus, blood concentration, Wuzhi-capsule