Abstract: AIM: To research the effects of Kanglaite (KLT) injection on anti tumor and expression of epidermal growth factor receptor (EGFR) in Lew is lung carcinoma (LLC). METHODS: A to tal of 40 C57BL/6 mice were randomly divided into four groups, including model group, KLT 6.25, 12.5, 25 mL/kg groups.All the mice were injected with 2 ×106 LLC cells at 1st day.A t the next day, mice in the K LT groups were peritoneally injected with KLT for 14 days.And at the 16th day, all the mice were sacrificed and the tumors were harvested.The tumor weight was measured and the tumor grow th inhibition rate was analyzed.The expression of EGFR was detected by westernblot.RESULTS: The growth of LLC was significant ly inhibited by KLT, the changes of tumor appearance and histology were affected and the expression level of EGFR was decreased.CONCLUSION: KLT injection could obviously inhibit the growth of LLC, whose mechanism maybe related to the inhibition of EGFR expression.

Key words: Kang laite injection, Lung carcinoma, EGFR