Effect on drug transport of OATP1A2

Abstract

Abstract: Organic anion transporting polypeptide 1A2(OATP1A2), expressed in liver, kidney, small intestine, blood-brain barrier and other organizations, is an important membrane transporter in humans. OATP1A2 mediates the trans-membrane transport of endogenous and exogenous materials, and plays a significant role in drug absorption, distribution and elimination. This review aimes to summarize the distribution, basic functions and gene polymorphism of OATP1A2, and its impact on drug transport.

Key words: Organic anion transporting polypeptide 1A2, Drug transport, Pharmacokinetics

CLC Number:

R969

PENG Dan, XIA Chun-hua, XIONG Yu-qing. Effect on drug transport of OATP1A2[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(4): 464-469.

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