Effects of bromocriptine, rosiglitazone and metformin on insulin resistance downregulating proinflammatory cytokines and metabolism of lipids in rats with polycystic ovary syndrome
LIN Jia, LIU Guang-nan, PAN Jing-qiang, KUANG Shao-song, HUANG Xiao-qiong, RAO Zi-liang
2010, 15(4):
391-396.
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AIM: To investigate effects of bromocriptine, rosiglitazone and metformin on insulin resistance (IR), proinflammatory cytokines, adipocytokines, blood glucose and lipid components in rats with polycystic ovary syndrome (PCOS). METHODS: The PCOS rats were molded by testosterone undecanoate and human chorionic gonadotropin (HCG), afterwards the rats were randomly divided into 4 groups: PCOS mold, bromocriptine, rosiglitazone and metformin; then all drugs were adiministered respectively by intragastric administration (i.g.) qd for 6 weeks. At the end of the experiment, the contents of fasting blood-glucose (FBG), 2-hours blood glucose after oral glucose tolerance test(OGTT-2 h BG), insulin, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), tumor necrosis factor (TNF-α),testosterone (T), insulin growth factor-1 (IGF-1), high sensitivity C-reactive protein(hs-CRP), leptin(L), adiponectin(A), resistin(R) were determined, and the changes of insulin sensitivity index (ISI) was counted. RESULTS: Compared with the normal group, concentrations of FBG, OGTT-2 h BG, Ins, hs-CRP, TNF-α, leptin, resistin, IGF-I, TC, TG, LDL-C and T were increased obviously(P<0.01), but ISI, adiponectin and HDL-C were decreased significantly (P<0.01) in PCOS rats. Bromocriptine, rosiglitazone and metformin could improve the pathologic changes in PCOS rats (P<0.01 or P<0.05). CONCLUSION: Bromocriptine, rosiglitazone and metformin can improve IR, hyperinsulinemia, hyperandrogenemia reduce blood glucose, adjust components of blood lipid, downregulate proinflammatory cytokines and regulate adipocytokines in PCOS rats.