Progress of the study on relations between renin angiotensin system and vascular remodeling of hypertension

Abstract

Abstract: Hypertensive vascular remodeling has always been a hot program in clinic and basic research.Renin-angiotensin system is an importent regulatory mechanism of human physiological function,which plays a fundamental role in vascular remodel- ing.RAS consists of two axes,ACE-AngII-AT₁ receptor axis and ACE2-Ang(1-7)-Mas receptor axis.The former affects vasoconstriction and promotes vascular re-modeling through its key member,AngII;the latter offsets the effect of the mentioned AngII with the help of seven-peptide Ang-(1-7). A deep knowledge of the relation between RAS and vascular remodeling would provide more remedies for reducing cardiovascular risk.

Key words: Hypertension, Vascular remodeling, Renin-angiotensin system

CLC Number:

R541

YUAN Yong-jie, WANG An-cai. Progress of the study on relations between renin angiotensin system and vascular remodeling of hypertension[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(4): 477-480.

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