Abstract: AIM: To study the effect of relieving cough and resolving phlegm among different species of Chuan Fritillaria. METHODS: (1)70 Healthy guinea pigs had been randomly divided to 7 groups: the Control group, the coughing model group, the Positive control group, the Fritillaria unibracteata Hsiao et K.C.Hsia group, the Fritillaria delavayi Ftanch group, the Fritillaria cirrhosa D.Don group and the Fritillaria przewalskii Maxim group. Continuously gave them herbs for 3 days. 60 s Citrate had been inhalated about 30 min after the last time of delivery. The Latency of cough and frequency of cough within 5 min were recorded.(2)60 Healthy mice had been randomly divided to 6 groups: the control group, the positive control group, the Fritillaria unibracteata Hsiao et K.C.Hsia group, the Fritillaria delavayi Ftanch group, the Fritillaria cirrhosa D.Don group and the Fritillaria przewalskii Maxim group. Continuously gave them herbs for 3 days. 30 min after the last time of delivery, 0.5 mL of 0.5% Phenol red solution had been intraperitoneally injected for each mouse. The mice were killed after 30 min. Mice's trachea had been separated and douched; 0.1 mL of 5% NaHCO₃ was added. After centrifuge manipulation, the supernatant had been divided. Enzyme labeling had been applied to measure the OD and eliminating phlegm index. RESULTS: (1) Compared with Fritillaria cirrhosa D. Don group, Fritillaria unibracteata Hsiao et K.C.Hsia group and the Fritillaria cirrhosa D.Don group could both prolong the latency of cough (P<0.05). (2) Compared with Fritillaria delavayi Ftanch group, Fritillaria cirrhosa D. Don group, Fritillaria przewalskii Maxim group and Fritillaria unibracteata Hsiao et K.C.Hsia group could increase the OD value of Phenol red excretion for mice's trachea(P<0.05, P<0.01). CONCLUSION: The Fritillaria unibracteata Hsiao et K.C.Hsia may have a better effect of resolving phlegm compared with Fritillaria delavayi Ftanch, Fritillaria cirrhosa D.Don and Fritillaria przewalskii Maxim. The Fritillaria unibracteata Hsiao et K.C.Hsia and Fritillaria delavayi Ftanch may have a better effect of relieving cough compared with Fritillaria cirrhosa D.Don and Fritillaria przewalskii Maxim.

Key words: Species, Fritillaria unibracteata Hsiao et K.C.Hsia, Fritillaria delavayi Ftanch, Fritillaria cirrhosa D. Don, Fritillaria przewalskii Maxim, Relieving cough, Resolving phlegm