Physiologically based gastrointestinal models for the prediction of oral drug absorption

Abstract

Abstract: Oral drug absorption is influenced by different physiological factors, such as composition of gastrointestinal fluid, pH, transit, transport and metabolism. The ability to accurately predict the oral drug absorption only depended on in vitro results, before preclinical or clinical researches will improve the efficient of drug development. Various physiologically based gastrointestinal models based on the profound understanding of oral absorption process provide an opportunity to assess in vivo oral absorption. These physiological models can link to classical pharmacokinetic models to predict the rate and extent of oral drug absorption. This paper reviews the principle and new application of these physiological models, then compare and discuss with those.

Key words: Physiologically based gastrointestinal models, Physiologically-based pharmacokinetic (PBPK) models, Advanced compartmental absorption and transit (ACAT) model, Advanced dissolution absorption, and metabolism (ADAM) model, Biopharmaceutics classification system

CLC Number:

R969.1

LI Guo-fu, YANG Jin, ZHANG Xue-ying, ZHAO Hao-ru. Physiologically based gastrointestinal models for the prediction of oral drug absorption[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(6): 656-662.

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