Comparison of the pharmacokinetics of BAPTA-AM liposome injection in rats and Beagle dogs

Abstract

Abstract: AIM: To compare the pharmacokinetics of BAPTA-AM liposome injection in rats and Beagle dogs. METHODS: The concentration of BAPTA-AM in plasma was quantified by LC-MS/MS after intravenous injection. The pharmacokinetic parameters were calculated by the non-compartment model. RESULTS: The elimination half-life in rats after intravenous injection 1.5, 3.0 and 6.0 mg/kg BAPTA-AM liposome were (255±140), (290±260)and (376±257)min respectively, and the AUC_0-∞ were(831±251), (1467±528)and(3650±1664) μg·L^-1·min, respectively. The elimination half-life in dogs after intravenous injection 0.5, 1.0 and 2.0 mg/kg BAPTA-AM liposome were (362±305), (347±278)and (432±292)min respectively, and the AUC_0-∞ were (400±118), (569±139)and (1185±640) μg·L^-1·min, respectively. CONCLUSION: After intravenous injection, BAPTA-AM liposome is metabolized rapidly and distributed abroad in rat and Beagle dog. There is no difference in the pharmacokinetic between rats and dogs.

Key words: BAPTA-AM, Liposome, Rat, Beagle dog, Pharmacokinetics

CLC Number:

R969.1

ZHENG Feng, LIU Wen-ying, WEI Wei. Comparison of the pharmacokinetics of BAPTA-AM liposome injection in rats and Beagle dogs[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(6): 663-667.

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