Effects of Sea Cucumber Capsule on the Parkinson's mouse induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine

Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2010, Vol. 15 ›› Issue (9): 1023-1026.

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Effects of Sea Cucumber Capsule on the Parkinson's mouse induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine

SHEN Xiong¹, MA Hai-bin², LI Lu-fan², LI Xiu-min², SONG Yu², ZHANG Xu-dong¹, MA Shi-ping²

¹Zhejiang HACON Pharmaceutical Co., Ltd, Hangzhou 310018, Zhejiang, China;
²Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, Jiangsu, China

Received:2010-06-09 Revised:2010-07-24 Online:2010-09-26 Published:2020-09-17

Abstract

Abstract: AIM: To investigate the effect of Sea Cucumber Capsule on the Parkinson's mouse induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP).METHODS: C57BL/6J mice were treated intraperitoneally with MPTP to prepare the PD model. The mice were treated with different doses Sea Cucumber Capsule for 14 days. The behavior tests of mice were observed and the contents of DA and its metabolites in the striatum of each group mice were detected by high performance liquid chromatography with electrochemical detection (HPLC-ECD).RESULTS: Sea Cucumber Capsule obviously enhanced the model mice's capability of motor coordination and prevented the destructive effect of MPTP. Sea Cucumber Capsule was effective against MPTP-induced neurodegeneration of the nigrostriatal dopaminergic neural pathway, and increasing DA and its metabolites' levels in the striatum.CONCLUSION: This study proves that Sea Cucumber Capsule could ameliorate the typical symptom of PD by protecting dopaminergic system.

Key words: Parkinson's disease, Sea Cucumber Capsule, MPTP

CLC Number:

R965.2

SHEN Xiong, MA Hai-bin, LI Lu-fan, LI Xiu-min, SONG Yu, ZHANG Xu-dong, MA Shi-ping. Effects of Sea Cucumber Capsule on the Parkinson's mouse induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(9): 1023-1026.

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Effects of Sea Cucumber Capsule on the Parkinson's mouse induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine

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