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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2010, Vol. 15 ›› Issue (9): 1051-1055.

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Analysis of the monitoring results and the influencing factors of blood concentration of valproate in patients with epilepsy

TANG Zhi-hua, ZHANG Ke-ying, XIAO Xing-feng   

  1. Zhejiang Shaoxing People's Hospital, Shaoxing 312000, Zhejiang,China
  • Received:2010-08-14 Revised:2010-09-12 Online:2010-09-26 Published:2020-09-17

Abstract: AIM: To analyse and investigate the monitoring results and influencing factors of blood concentration of valproate in patients with epilepsy.METHODS: The serum concentrations of valproate in 276 patients were determined by fluorescence polarization immunoassay and the results were analyzed.RESULTS: 71.7% of the results of blood drug concentration were in the reference range. The concentration of the sustained-release tablets was significantly higher than the conventional dosage forms (P<0.01). The occurrence of adverse drug reactions was associated with the drug concentration. The influencing factors of valproate concentration including physiological and pathological factors in patients,dosage forms and the quality of preparation, patient compliance, sampling time and method, monitoring time, combination therapy, the accuracy of medical order execution and involvement of pharmacists in clinical medicine therapy, etc.CONCLUSION: In therapeutic drug monitoring of valproate, it should be concerned about the impact factors of valproate concentration to ensure the safety and efficacy in patients.

Key words: Valproate, Serum concentration, Impact factor, Epilepsy

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