Abstract: AIM: To investigate the association between plasma lipid and acute cerebral accident, evaluate the correlation between abnormal lipid metabolism and arteria carotis atherosclerotic in cerebral infarction.METHODS: The concentration of plasma lipid was detected in 172 cerebral hemorrhage patients, 498 cerebralinfarction patients and 118 healthy controls. And arteria carotis atherosclerotic plaque was detected in all cerebral infarction patients and healthy controls.RESULTS: The TC, TG, LDL-C levels in cerebral infarction patients were significantly higher than those in control. The TC levels in cerebral hemorrhage patients were significantly higher than those in control. The incidence of carotid atherosclerotic plaque in cerebral infarction patients was significantly higher than that in control (P<0.01). The incidence of lipid metabolic disturbance was significantly rising in cerebral infarction patients with positive incidence of carotid atherosclerotic plaque compared with negative incidence of carotid atherosclerotic plaque (P<0.01). The TG,TC,LDL-C levels in cerebral infarction patients with positive incidence of carotid atherosclerotic plaque were significantly increased as compared with negative incidence of carotid atherosclerotic plaque. CONCLUSION: High plasma TC,TG and LDL-C showed associated with cerebral infarction. Plasma TC showed associated with cerebral hemorrhage. There is a close correlation between carotid atherosclerotic plaque and lipid metabolic disturbance. Carotid atherosclerotic plaque is an important risk factor for cerebral infarction.

Key words: Cerebral infarction, Cerebral hemorrhage, Plasma lipid, Carotid atherosclerotic plaque, Lipid lowering therapy