Application and prospects of 5-HT receptor antagonists in the prevention and treatment of pulmonary hypertension

Abstract

Abstract: Pulmonary hypertension is a group of clinical pathophysiological syndrome characterized by increased pulmonary vascular resistance due to multiple etiologies and pathogenesis. The main clinical manifestations are right ventricular dysfunction with poor prognosis, and patient of severe right heart failure can even cause death. This article reviews the relationship between the 5-HT and pulmonary hypertension, and the 5-HT receptor antagonists' effects on the prevention and treatment of pulmonary hypertension. The article also prospects that 5-HT receptor antagonists may be a kind of very promising new drugs in the treatment of pulmonary hypertension.

Key words: 5-hydroxytryptamine, 5-hydroxytryptamine receptor, Antagonist, Pulmonary artery hypertension , , , ,

CLC Number:

R543.2

XIAO Xiong, HOU Ying, LI Xiao-qiang. Application and prospects of 5-HT receptor antagonists in the prevention and treatment of pulmonary hypertension[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(1): 111-115.

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