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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2011, Vol. 16 ›› Issue (10): 1132-1136.

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Sample size estimation in randomized controlled drug clinical trials

LI Chan-juan, JIANG Zhi-wei, WANG Rui, XIA Jie-lai   

  1. Department of Health Statistics, Fourth Military Medical University, Xi'an 710032,Shaanxi,China
  • Received:2011-07-08 Revised:2011-09-03 Online:2011-10-26 Published:2011-11-02

Abstract: Sample size estimation is a key research aspect in randomized controlled drug clinical trial. Sample size estimation factors, parameters and basic rules are discussed in our research. In addition, sample size estimation procedures are introduced based on two examples. A reference is provided for estimating sample size in randomized controlled clinical trials.

Key words: Clinical trials, Sample size estimation, Test power

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