Abstract: AIM: To study the effect of Shenmai Injection for gastrointestinal tumor patients after operation with oxaliplatin chemotherapy on blood tests and CD₄/CD₈ level.METHODS: Eighty cases of gastrointestinal tumor patients after operation with oxaliplatin chemotherapy were divided into single group and combined group, each 40 cases. The single group was administered by chemotherapy only while the combined group by chemotherapy and Shenmai Injection. After 6 cycle chemotherapy, TCM symptoms integral, neutrophils, CD₄/CD₈ ratio were compared between two groups.RESULTS: Compared with the single group, the TCM symptoms integral of the combined group was less (P<0.01). Compared with the single group, the neutrophils level of the combined group was less (P<0.05). Compared with the single group, the CD₄ level and CD₄/CD₈ ratio were more and statistically significant (P<0.05).CONCLUSION: Shenmai Injection can improve chemotherapy related symptoms and reduce bone marrow toxicity; it can also adjust chemotherapy patient's immune status and ensure chemotherapy smoothly.

Key words: Shenmai Injection, Tumor, Blood routine, CD₄/CD₈