Effects of insulin treatment on blood lipid in type 2 diabetic KK mice

Abstract

Abstract: AIM: To study the effect of intraperitoneal and subcutaneous insulin administration on serum lipids in a type 2 diabetic animal model (KK mice).METHODS: KK mice with fasting blood sugar level higher than 20 mmol/mL were set as type 2 diabetic model and divided into subcutaneous injection group(s.c. group, n=9) and introperitoneal injection group(i.p. group, n=9). C57BL mice were set as normal control(C group, n=10). The type 2 diabetic KK mice were given high glucose and fatty for 4 weeks. Meanwhile, insulin was administrated at doses of 0.4 mL/d for s.c. group and 0.3 mL/d for i.p. group to normalize fasting blood glucose concentration(6.0 mmol/L±1.5 mmol/L).RESULTS:After the diabetic KK mice were treated with insulin for 2-4 weeks, the serum TG, TC, LDL-C and HDL-C were recovered to the normal scope by intraperitoneal injections of insulin, but TG, LDL-C and HDL-C were not recovered to the normal level by subcutaneous injections of insulin.CONCLUSION: This result indicates that compared with subcutaneous insulin administration, intraperitoneal insulin administration is more efficacious to correct the disorder of lipid metabolism.

Key words: Diabetes mellitus, Insulin, Lipid metabolism

CLC Number:

R965.2

ZHANG Chao, DENG Shan-shan, XU Rong, WANG Xin-ran, TANG Li-na, XIANG Li, SUN Hong-fan. Effects of insulin treatment on blood lipid in type 2 diabetic KK mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(2): 130-134.

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