Protective effects of MC-002 on anti-stroke in rats

Abstract

Abstract: AIM: To investgate the protection effects of 3-methoxy－4-O-(2'-methyl radical-3'5'6'- trimethyl pyrazinyl) cinnamic acid (MC-002) on anti-stroke in rats by antihypertensive therapy.METHODS: RHRSP (stroke prone renovascular hypertensive rats) model was reproduced to initiate 2K1C renal hypertension, and the stroke was accelerated by high sodium intake. The effect of MC-002 at different doses on rats' neurological symptom,body weight, blood pressure and pathological section of brain tissues were examined after the administration by i.v. injections.RESULTS:MC-002 can significantly improve the rats' neurological symptom and decrease blood pressure(P<0.01);MC-002(30 and 18 mg/kg) can markedly inhibit the dropping of rats' bodyweight(P<0.01);the pathological observations showed that neuronal cells shape and number were obviously improved after treated with MC-002.CONCLUSION: As a new Ca²⁺ antagonist and scavenger of free radicals, MC-002 has notable effects of stroke protection in rats by antihypertensive therapy.

Key words: MC-002, Stroke, Protective effect

CLC Number:

R544.1

ZENG Sheng-nan, WU Yu-lin, HE Guang-wei, WU Qiang. Protective effects of MC-002 on anti-stroke in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(2): 139-143.

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