Abstract: AIM: To observe the protective effect of phosphocreatine sodium on adriamycin-induced cardiotoxicity in mice.METHODS: 60 female BALB/C mice weighting about 20 g were randomly divided into control group (Con), adriamycin group (ADR) and phosphocreatine sodium treatment group (CP). The general condition, the serum myocardial enzymes of NT-proBNP and TnI, the changes of MDA, SOD, LDH and ATPase in cardiac tissues were detected. The changes of cardiac tissues were observed by HE staining.RESULTS: Compared with group ADR, the contents of MDA and LDH were reduced in mice cardiac tissues, the activity of ATPases and SOD was elevated in mice cardiac tissues (P<0.05),the serum levels of TnI and NT-proBNP were decreased in group CP(P＞0.05). Intracellular edema and nuclear degeneration were obviously observed in adriamycin-treated cardiac tissues by HE staining.CONCLUSION: Phosphocreatine sodium protects mice from cardiotoxicity induced by adriamycin. The reduction of oxygen free radicals in mice cardiac tissues may be involved in the protective effect of phosphocreatine sodium.

Key words: Phosphocreatine sodium, Adriamycin, Myocardial enzyme, Oxygen free radicals