Abstract: AIM: To study and compare the effects of the three different recipes of Tanreqing oral liquid on antibacterial and antiviral activity.METHODS: The antibacterial experiments in vivo and in vitro were carried out respectively. The mice were infected with influenza virus FM1 from nose.RESULTS: All of them could decrease the death rate of mice infected with staphylococcus aureus or beta-hemolytic streptococci and had bacteriostasis and batericidal activity in vitro. The oral liquid containing ursodeoxycholic acid was the best. They also could decrease the death rate of virus infected mice and prolong the survival time obviously. Tanreqing oral liquid containing ursodeoxycholic acid or bear gall powder could reduce the lung index obviously and it had less activity if there were none of them. The effects of the three oral liquid on the grade of the lung pathological changes were not significant vs model group.CONCLUSION: They could provide protection from bacterium and influenza virus. The antiviral activity of Tanreqing oral liquid containing ursodeoxycholic acid was the same as which containing bear gall powder. And the antibacterial activity of the former was better than the latter.

Key words: Tanreqing oral liquid, Antibacterial, Antiviral, Mouse