Abstract: AIM: To compare the curative effects between domestic and imported pulmonary surfactant on neonatal respiratory distress syndrome (NRDS).METHODS: 54 neonates with NRDS were randomly divided into Calsurf group (domestic pulmonary surfactant, 28 cases) and Curosurf group (imported pulmonary surfactant 26 cases) .At the basic of conventional therapy, the two groups received domestic or imported pulmonary surfactant with single dose by intratracheal administration, respectively. The curative effects and adverse reaction were observed.RESULTS: Before using these drugs, the patients in two groups were all with hypoxemia, the artery - alveolar pressure ratio (a/APO₂) and PaO₂/FiO₂ were increased significantly after 30 minutes. The gas exchange function was improved; the breathing machine parameters were lowered 72 minutes later. Two drugs could significantly reduce mechanical ventilation of time and improve the success rate of treatment.CONCLUSION: Both the domestic and imported pulmonary surfactant have the same good curative effects and safety on neonatal NRDS.

Key words: Neonatal, Respiratory distress syndrome, Pulmonary surfactant