Efficacy and electrocardiogram abnormality of olanzapine in the treatment of old schizophrenic patients

Abstract

Abstract: AIM: To explore the efficacy and the electrocardiogram abnormality of olanzapine or risperidon in the treatment of old schizophrenic patients.METHODS: 120 patients with old schizophrenia were randomly divided into olanzapine group (60 cases) and risperidon group(60 cases) treated for 8 weeks. The efficacy was measured with the positive and negative symptoms scale (PANSS) and PANSS and the electrocardiogram test was used to evaluate the efficacy and adverse effects respectively before and at the ends of 2,4,6,8 weeks of treatment. The amount and information of electrocardiogram abnormality were analyzed.RESULTS: The efficacy rate of olanzapine was 78.3%,in which 56.7% was improved markedly. The efficacy rate of risperidon was 75.0%, in which 51.7% were improved markedly. There were no difference between two groups(P>0.05). There were significant differences on extrapyramidal side effect and liver function between them. At the 2nd week, the efficacy of olanzapine was more than that of the risperidon(P<0.05). There were significant difference in electrocardiogram abnormality between olanzapine group and risperidon group(P<0.05).CONCLUSION: There are no significant differences in the efficacy and the electrocardiogram abnormality between two groups. Olanzapine has less side-effect especially. The two drugs adapt to old schizophrenic.

Key words: Olanzapine, Risperidon, Old, Schizophrenia , PANSS, Electrocardiogram

CLC Number:

R749.3

YUAN Guo-feng, YU Yu-li. Efficacy and electrocardiogram abnormality of olanzapine in the treatment of old schizophrenic patients[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(3): 304-308.

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