Abstract: AIM: To investigate effects of analgesia with parecoxib combined morphine on patient controlled analgesia and pulmonary function in patients after abdominal opertion.METHODS: Fifty patients were randomly allocated to Parecoxib group (group P, n=25) and Morphine group (group M, n=25). Both group received PCA with morphine (1 mg/mL) . Group P received intravenous parecoxib 40 mg while the PCA pump beginning, 12,24 and 48 h after the first dose. Group M received intravenous normal saline at the same four point. The following indexes were recorded at 12, 24, 36 and 48 hours after the PCA pumps were used: VAS scores of pain, sedation score, demanded delivery, effective delivery, drug dose, and side effects. To compare parameters of pulmonary function in postoperative 24,48 and 72 h between the two groups.RESULTS: Compared with group M , there were significant decreases in VAS scores of pain at 12, 24, 36 and 48 hours after the PCA pumps were used(P<0.05). Sedation score, demanded delivery, effective delivery and drug dose in group P were obviously lower than those in group M(P<0.05). The incidence rate of nausea in group P was obviously lower than that in group M(P<0.05). FVC% and FEV1% were significantly higher in postoperative 24 and 48 h in treatment group than those in control group (P<0.05). PaCO₂ were significantly lower in postoperative 24 h in treatment group than that in control group (P<0.05).CONCLUSION: Parecoxib can relief pain in patient after abdominal opertion safely and efficiently, reduce the morphine consumption and improve pulmonary function.

Key words: Parecoxib Sodium, Morphine , Analgesia, patient-controlled , Pulmonary function