Abstract: AIM: To retrospectively analysis the clinical effect of ¹³¹I therapy of Graves disease and some correlative factors.METHODS: The effects of some factors which including gender,age,thyroid weight and ¹³¹I dose on the cure rate and the incidence rate of hypothyroidism were observed,through the follow-up of 406 cases between 12 and 29 months of ¹³¹I therapy of patients with Graves disease in our hospital.RESULTS: 406 patients,the follow-up showed that the therapy was recovered in 248(61.08%),effective 155(38.18%),became hypothyroidism in 118(29.06%),failure in 3(0.74%).Totally, 99.26% patients were responsed to the intervention.The gender and age were no significant difference to the incidence rate of hypothyroidism and cure rate after ¹³¹I in the initial treatment of Graves disease(P>0.05). Thyroid weight and dose of ¹³¹I showed significant difference to the incidence rate of hypothyroidism and cure rate(P<0.01).CONCLUSION: Idine-131 therapy is preffered for patients with graves disease because of being efficient,convenient and secure. The difference of thyroid weight and dose of ¹³¹I do significant influence to the incidence rate of hypothyroidism and cure rate.

Key words: Graves disease, ¹³¹I, Incidence rate of hypothyroidism, Cure rate