Abstract: AIM: To compare the clinical effect of combination of captopri with amlodipine and monotherapy of amlodipine, and the influence on the serum uric acid level.METHODS: 80 patients with mild to moderate essential hypertension were selected and divided into two groups. 40 patients of the study group were treated with captopri (25 mg/capsule, bid) and amlodipine (5 mg, q.d.) for 8 weeks, 40 patients of the control group were treated with amlodipin (5 mg, q.d.) for 8 weeks. The efficacy of both groups was evaluated by comparing the variance of blood pressure and serum uric acid.RESULTS: The blood pressure of the combined therapy was decreased from (98±7)mm Hg to(92±8) mm Hg after 4 weeks and to (86±11)mm Hg after 8 weeks, the difference is statistically significant (P<0.05). The blood pressure of the monotherapy group was (96±8) mm Hg, which is not statistically significant different from (95±7) mm Hg after 4 weeks. The blood pressure of the monotherapy group was (90±8)mmHg after 8 weeks, which is significantly different from (96±8) mm Hg (P<0.05). The decreased extent of the combined therapy group was significantly different from the monotherapy group. The serum uric acid of the two groups were decreased and the decreased extent of the combined therapy was significant than that of monotherapy group.CONCLUSION: The combined therapy for the mild to moderate essential hypertension is an effective strategy and can protect the organ.

Key words: ACE inhibitor, Calcium antagonist, Hypertension, Effect, Serum uric acid