Free radical scavenging mechanism of edaravone and its clinical application

Abstract

Abstract: Researches certified that overproduction of free radicals has been implicated in many human diseases , as excessive free radicals damage biomacromole- cules such as lipids ,protein and DNA , leading to deleterious effect of the body. Edaravone, a potent free radical scavenger, has been approved in Japan for the treatment of acute cerebral infarction since April 2001. This review illustrated the hypothetical free radical-scavenging mechanism of edaravone and summarized the research progress of edaravone in treating many human diseases. The protective effect of edaravone in treating ischemic/reperfusion injury in many organs( brain, heart et al), neurodegenerative diseases(Amyotrophic Lateral Sclerosis, Parkinson's disease, Alzheimer's disease et al), epilepsy, atherosclerosis, hepatic fibrosis and pulmonary fibrosis diseases, rheumatoid arthritis and sudden hearing loss are described in this review, which may provide reference for the novel clinical application of edaravone in future.

Key words: Edaravone, Free radical, Oxidant stress

CLC Number:

R969

MA Li-ping, SUN Jian-guo, PENG Ying, WANG Guang-ji. Free radical scavenging mechanism of edaravone and its clinical application[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(3): 341-348.

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