Preclinical pharmacology research of oxiracetam

Abstract

Abstract: It has been more than 20 years since the birth of nootropic drug oxiracetam, extensive and deep research has been focused on its pharmacological features in china and abroad. As a general pharmacologically inactive and non-toxic cognition enhancer, it possesses good pharmacokinetics characteristics. The pharmacological effects of oxiracetam include the improvement of learning and memory and neuroprotective function. The mechanism of its action may involve: the effect on central acetylcholine system and the interaction between other neurotransmitter systems associated with cognition (such as glutamate system, monoamine neurotransmitter system) and the cholinergic system, induction and maintenance of LTP, activation of protein kinase C, promotion of brain metabolism, the impact of peripheral steroid hormones, etc.

Key words: Oxiracetam, Nootropic, Cognition enhancer, Learning and Memory, Neuroprotective

CLC Number:

R961

JIN Lei, LI Bo, YE Lei, CAI Yun-Hong, RONG Zu-Yuan. Preclinical pharmacology research of oxiracetam[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(3): 354-360.

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