Abstract: AIM: To compare the clinical effect and safty of Parocetine and Citalopram on treatment of depressive patients with attempted suicide.METHODS: Using randomized study, 75 cases depressive patients with attempted suicide were evaluated by Hamilton rating scale for depression(HAMD) and Treatment emergent symotoms(TESS).RESULTS: The effective rate of Parocetine after 4 weeks treatment was lower than that of Citalopram (P<0.05).There was significance difference. The significant efficiency had significance difference in two groups after 4 weeks treatment (P<0.05). The side effects of Parocetine and Citalopram had no differences(P＞0.05).CONCLUSION: Citalopram is rapidly responsive antidepressant for depressive patients with attempted suicide, and safty of Parocetine and Citalopram are similar.

Key words: Depressive disorder, Attempted suicide, Parocetine, Citalopram