Abstract: AIM: To observe the effects of penehyclidine hydrochloride on blood pressure(BP),heart rate (HR),oxyhernoglobin saturation by pulse oxygen saturation (SpO₂),and gland secretion in patients undergoing surgery of chest.METHODS: Sixty patients undergoing surgery of chest were randomly divided into 3 groups,in which the patients were intravenously injected with 2 mL of normal saline(group A),0.01 mg/kg of atropine(group B),0.01 mg/kg of penehyclidine hydrochloride(group C),20 minutes before the induction of anesthesia,respectively.In all patients,BP,HR,SpO₂, visual analog scale(VAS)scores for thirst,and the tracheal and salivary secretion volume were determined both before and after the injection.RESULTS: Compared with baseline,HRin group C were significantly lower (P<0.05).In group B,HR significantly increased after the injection of atropine (P<0.05).SpO₂ in group A and group B and group C were no differences(P>0.05).The VAS scores for thirst in group C was significantly lower than those in group B 10 minutes after injection and after extubation(P<0.05),and the VAS scores for thirst in group C was significantly higher than those in group B one hour after extubation.CONCLUSION: Penehyclidine hydrochloride(0.01 mg/kg) injected intravenously before operation can decrease salivary secretion effectively without increasing HR and BP.

Key words: Penehyclidine hydrochloride, Surgery of chest, Hemodynamics, Gland secreting