Abstract: AIM: To study the efficacy and safety of complex lidocaine crem used in polyp of cord resection.METHODS: Forty patients who need such operation, were randomly divided to two groups, the trial group and control group. There were 20 patients in each group. The trial group used complex lidocaine crem besmear on the front 1/3 of the tracheal catheter. The control group did not use the drug on the tracheal catheter. The heart rate(HR), the mean aortic pressure(MAP) and the SpO₂ were recorded at beforeoperation(T1),just before tracheal intubation(T2), 5 min after tracheal intubation (T3), operation completeted (T4), just after extubation (T5), 5 min after extubation(T6), 10 min after extubation (T7).The cases who have bucking, foreign body sensation and throat pain were also recorded, the toxic symptom of local anesthetic was observed.RESULTS: There were no significant differences at T1-T5 between two groups of HR, MAP and SpO₂ (P>0.05) .The HR,MAP in trial group were significantly lower than those in control group at T6 and T7(P<0.05) .The HR and MAP were significant higher in control group than those in trial group at T5. The SpO₂ had no difference between two groups (P>0.05).There were no significant differences between two groups in the cases who had bucking (P>0.05).There were more throat pain patients in control group than in trial group (P<0.05).The foreign body sensation patients in experiment group were more than in control group (P<0.05).There were no toxic symptom of local anesthetic in all studied patients.CONCLUSION: The complex lidocaine crem used in polyp of cord resection operation can reduce stimulation during extubation, lessen the throat pain after operation. But it can make patient feel the postoperation foreign body sensation. There were no patients emerging toxic symptom of local anesthetic. The complex lidocaine crem can be used in polyp of cord resection efficiently and safely.

Key words: Complex lidocaine crem, Polyp of cord resection, Efficacy, Safety