Abstract: AIM: To investigate the effects of dexmedetomidine on hemodynamics and sedation in senile patients with hypertension undergoing cataract surgery.METHODS: 40 senile patients with hypertension scheduled undergoing elective phacoemulsification surgery were enrolled and randomly assigned to observation group(dexmedetomidine, n=20) and control group(normal saline, n=20). Blood pressure, heart rate and pulse oxygen saturation in both groups were observed. Sedation score and dosage of vasoactive drugs were recorded.RESULTS: The levels of systolic blood pressure(SBP), diastolic blood pressure(DBP) and heart rate(HR) in intraoperative were decreased of different degrees (P<0.05 or P<0.01), but there were no additional vasoactive agents were administered in observation group. Whereas patients in the control group, the levels of SBP, DBP and HR were increased (P<0.05 or P<0.01),furthermore 7 patients required vasoconstriction drugs.Two groups of patients in a state of oxygen, pulse oxygen saturation were close to 100%. In observation group, the level of sedation score was higher than that in control group (P<0.05).CONCLUSION: Monitored anesthesia care under dexmedetomidine can provide optimal sedation, appropriate analgesia and stable hemodynamics in senile patients with hypertension undergoing cataract surgery.

Key words: Dexmedetomidine, Monitored anesthesia care, Cataract, Hypertension