Abstract: AIM: To observe the effect of penehyclidine hydrochloride on intrapulmonary shunt and inflammatory factors in lung cancer surgery.METHODS: Thirty patients with lung cancer undergoing lung resection were randomly divided into two groups with 15 cases each: penehyclidine hydrochloride group (group A) and atropine group (group B). Blood gas analysis, TNF-α, IL-6, IL-8, SOD and MDA concentrations were detected at two lung ventilation(TLV) (T₁, baseline), OLV 45 min(T₂), OLV 90 min (T₃) and 2 h, 24 h after operation(T₄, T₅).RESULTS: SPO₂, PaO₂ were lower in group B than those in group A, Qs/Qt was higher than group A at T_2-4 (P＜0.05). Serum TNF-α, IL-6, IL-8 SOD concentrations were lower at T_3-5 in group A than those in group B (P＜0.05). Serum MDA concentration was higher at T_3-4 in group B than in group A.CONCLUSION: Penehyclidine hydrochloride could reduce intrapulmonary shunt and alleviate the pulmonary inflammatory reactions in lung cancer surgery.

Key words: Penehyclidine hydrochloride, One lung ventilation, Intrapulmonary shunt, Inflammation factors