Relationship between PGE2,its correlation factors and TNF-α in rheumatoid arthritis and the regulation of drug

Abstract

Abstract: Rheumatoid arthritis(RA) is a common chronic, inflammatory, systematic autoimmunity disease.Tumor necrosis factor (TNF-α) and prostaglandin E₂ (PGE₂) are major inflammatory mediators in RA.A lot of compounds are available to treat RA,but most of anti-rheumatic drugs only stay in controlling inflammation symptom and can't modify the progression of the disease, simultaneously accompany with severe side adverse effect.The article reviews the relationship between PGE₂,its correlation factors and TNF-α in rheumatoid arthritis and the therapeutic effect of drugs on RA.

Key words: Rheumatoid arthritis, Tumor necrosis factor alpha, Prostaglandin E₂

CLC Number:

R593.22

ZHANG Lei, WEI Wei. Relationship between PGE₂,its correlation factors and TNF-α in rheumatoid arthritis and the regulation of drug[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(8): 951-955.

References

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Relationship between PGE₂,its correlation factors and TNF-α in rheumatoid arthritis and the regulation of drug

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