Abstract: AIM: To compare the clinical efficacy and safety of ⁹⁹Tc-MDP and alendronate therapy on senile osteoporosis. METHODS: Adult patients (n=80) with senile osteoporosis were randomized into Group alendronate (n=40)and Group ⁹⁹Tc-MDP(n=40), all patients were given full dosage of calcium agent and vitamin D therapy. Group alendronate (n=40) were given alendronate; Group ⁹⁹Tc-MDP(n=40) were given ⁹⁹Tc-MDP.After treatment,the efficacy was evaluated by the digital analog score (VAS)of the pain and detecting bone mineral density(BMD). RESULTS: After treatment,the lumbodorsal pain scores were decreased in two groups.While the efficacy of odynolysis in Group ⁹⁹Tc-MDP was faster and better than that in Group alendronate(P＜0.05); the BMD of two groups were increased to some extent, the peak clinical efficacy appeared at six months in Group ⁹⁹Tc-MDP(P＜0.05). CONCLUSION: ⁹⁹Tc-MDP decreases pain more quickly and obviously,and can also increase the BMD in patients with severe senile osteoporosis. Alendronate shows higher safety in long-term treatment of senile osteoporosis.

Key words: Senile osteoporosis, ⁹⁹Tc-MDP, Alendronate