Effects of silybin on inhibiting glycoxidative stress and improving the learning and memory in aging rats treated by D-galactose

Abstract

Abstract: AIM: To investigate the effects of silybin on the glycoxidative stress and the abilities of learning and memory in aging rats induced by D-galactose.METHODS: The aging rats induced by D-galactose, the abilities of learning and memory were measured by Morris water maze test in rats.To assess the glycoxidative stress, the glycosylated hemoglobin(HbA1c) and fructosamine (FRA), advanced glycation end products(AGEs) in plasma,the activity of aldose reductase(AR) in red blood cell (RBC) were used , the levels of malondialdehyde (MDA) and AGEs and ability of superoxide dismutase(SOD) in brain tissue were also acquired.RESULTS: Compared with the control group, Sily groups(150 mg/kg and 75 mg/kg ) obviously inhibited the activity of AR(P<0.01), reduced the levels of FRA, HbA1c and AGEs in rats treated by D-galactose(P<0.01 or P<0.05), and the levels of MDA and AGEs were reduced while the activity of SOD in brain were elevated(P<0.01).CONCLUSION: Silybin could improve the abilities of learning and memory in rats treated by D-galactose, and it might be related to the inhibition of glycoxidative stress and ability of AR.

Key words: Silymarin, Aging, D-galactose, Glycoxidative stress, Learning and memory

CLC Number:

R965.2

FU Yong-jin, PAN Jing-qiang, ZHANG Xiao-mu, KUANG Shao-shong. Effects of silybin on inhibiting glycoxidative stress and improving the learning and memory in aging rats treated by D-galactose[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(1): 10-14.

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