Abstract: AIM: To observe the protection effect of modified Wuweixiaoduyin extracts (MWE) on peridentalt of diabetic rats and investigate its possible mechanisms. METHODS: Diabetic periodontitis models were induced by combination periodontal ligation and injection of streptozotocin (STZ, 50 mg/kg). There were 5 experimental groups as followed: Normal, model groups, Aminoguanidine (AG) positive control groups (100 mg/kg), low dosage (20 g/kg, crude drug, the same below) and high dosage (40 g/kg) of MWE, with 10 rats in each group. Rats were killed after treatment for 6 weeks, the levels of fasting blood glucose and glycosylated hemoglobin (GHb) were determined, AGEs in serum was analyzed by ELISA. Depth of periodontal pocket was measured by periodontal probe. Left alveoli dentales maxillae were checked by dental X machine. In addition, expression of RAGE protein was detected by sABC methods.RESULTS: After treatment for 6 weeks, MWE didn't decrease blood glucose. However, compared with model group, MWE decreased depth of periodontal pocket, level of GHb and AGEs in serum (P<0.01). And derangement of Trabeculae bone and horizontal resorption in alveoli dentales maxillae were also ameliorated. In addition, expression of RAGE protein was reduced, too. CONCLUSION: MWE has protection effect on peridental of diabetic rats and the possible mechanism is related with interference AGEs-RAGE by MWE .

Key words: Modified wuweixiaoduyin, Diabetic mellitus, Periodontitis, AGEs, RAGE, Inflammatory reaction