Meta-Analysis of ACEI combined with ARB on the effect of renal function with Diabetic Nephropathy

Abstract

Abstract: AIM: To evaluate the clinical treatment effects on renal function of angiotensin-converting enzyme inhibitors (ACEI) combined with angiotensin II receptor blocker (ARB) in patients with diabetic nephropathy (DN). METHODS: Retrieve the domestic literatures for the randomized controlled clinical trials about ACEI/ARB combined or mono-therapy on renal function in DN patients during the period January 1990 to March 2012.The difference of indicators for the renal function before and after treatment for the included literaturs was carried out RevMan 5.0 software. RESULTS: Total of 12 studies, including 900 cases of patients with DN, were included in this study. Meta-analysis showed that compared with ACEI or ARB mono-therapy, the combined treatment affection on the standardized mean difference for 24-hour urinary albumin excretion rate, 24-hour urine albumin and 24 urinary protein were significantly improved (P<0.05). However, there was no significant difference of serum creatinine, blood urea nitrogen and electrolytes between two groups.CONCLUSION: Compared with mono-therapy, ACEI and ARB combined treatment could exert anti-proteinuria effects in patients with DN, but no improvement on the serum creatinine, blood urea nitrogen and electrolytes. However, further large-scale trials are required to define the role of ACEI and ARB combined treatment in patients with DN.

Key words: Diabetic nephropathy, ACEI, ARB, Renal function, Meta- analysis

CLC Number:

R277.592

HAN Su-fang. Meta-Analysis of ACEI combined with ARB on the effect of renal function with Diabetic Nephropathy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(11): 1257-1262.

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