Abstract: AIM: To observe the analgesic effects of dezocine combining with flurbiprofen in patient controlled intravenous analgesia (PCIA) after posterior spinal approach. METHODS: Sixty patients undergoing posterior spinal internal fixation surgery were equally randomized into two groups : dezocine combining with flurbiprofen group (Group DF, n=30 ) , and sufentanil group (Group S, n=30) . Visual analogue scale (VAS) in the quiet time and movement in the stand, and Ramsay sedation scale were evaluated at 1,4, 8, 12, 24,36 and 48 h after surgery ; the number of effective compression ratio and the actual number of pressing within 48 h PCA,patient satisfaction with pain,overall assessment of pain patients and the incidence of adverse reactions were also recorded. RESULTS: The two groups were able to provide good postoperative analgesia, the number of effective compression ratio and the actual number of pressing were similar (P>0.05). DF group's VAS scores movement in the stand,patient satisfaction with pain and overall assessment of pain patients were significantly better than those in the S group(P<0.05), and had lower incidence of adverse reactions(P<0.05). CONCLUSION: Dezocine combining with flurbiprofen can provide satisfactory postoperative analgesia after posterior spinal approach,and has lower incidence of adverse reactions.

Key words: Dezocine, Flurbiprofen, Postoperative analgesia, Spine