Abstract: AIM: To explore whether Chinese Traditional Medicine such as alismatales, plantaginaceae and smilax glabra can regulate the hyperuricemia mice uric anionic exchanger 1(URAT1) mRNA expression of rats. METHODS: The 48 Wistar rats were randomly divided into control group, model group, benzbromarone group, alismatales group, plantaginaceae group and smilax glabra group. There were 8 rats every group. Alismatales, plantaginaceae,smilax glabra and benzbromarone were given to rats with hyperuricemia model established with potassium oxonate. The quantitative Real-time PCR method was used for detection of URAT1 mRNA gene expression. RESULTS: The blood uric acid level of benzbromarone group, alismatales group, plantaginaceae group and smilax glabra group were significantly lower than those in the model group (P<0.01). The expression of URAT1 mRNA in benzbromarone group, plantaginaceae group, benzbromarone group were lower than those in model group. CONCLUSION: The mechanism for plantaginaceae and smilax glabra may be relevant in inhibiting URAT1 gene mRNA expression of rats, thus accelerating the excretion of uric acid.

Key words: Plantaginaceae, Smilax glabra, Uric acid, URAT1, Gene expression